Systems Genetics Linking Genotypes Phenotypes Hardcover 9781107013841 VG

Description: Systems Genetics: Linking Genotypes and Phenotypes (Cambridge Series in Systems Genetics) Cambridge University Press Hardcover Unused and unread, cosmetic imperfections such as scuffs, creases or knocks. Stamped 'damaged' by publisher to a non-text page. EAN: 9781107013841 Published: 02/07/2015 Language: English Whereas genetic studies have traditionally focused on explaining heritance of single traits and their phenotypes, recent technological advances have made it possible to comprehensively dissect the genetic architecture of complex traits and quantify how genes interact to shape phenotypes. This exciting new area has been termed systems genetics and is born out of a synthesis of multiple fields, integrating a range of approaches and exploiting our increased ability to obtain quantitative and detailed measurements on a broad spectrum of phenotypes. Gathering the contributions of leading scientists, both computational and experimental, this book shows how experimental perturbations can help us to understand the link between genotype and phenotype. A snapshot of current research activity and state-of-the-art approaches to systems genetics are provided, including work from model organisms such as Saccharomyces cerevisiae and Drosophila melanogaster, as well as from human studies. List of contributors 1. An introduction to systems genetics Florian Markowetz and Michael Boutros 2. Computational paradigms for analyzing genetic interaction networks Carles Pons, Michael Costanzo, Charles Boone and Chad L. Myers 3. Mapping genetic interactions across many phenotypes in metazoan cells Christina Laufer, Maximilian Billmann and Michael Boutros 4. Genetic interactions and network reliability Edgar Delgado-Eckert and Niko Beerenwinkel 5. Synthetic lethality and chemoresistance in cancer Kimberly Maxfield and Angelique Whitehurst 6. Joining the dots network analysis of gene perturbation data Xin Wang, Ke Yuan and Florian Markowetz 7. High content screening in infectious diseases new drugs against bugs AndrÃƒÂ P. MÃƒÂ¤urer, Peter R. Braun, Kate Holden-Dye and Thomas F. Meyer 8. Inferring genetic architecture from systems genetics studies Xiaoyun Sun, Stephanie Mohr, Arunachalam Vinayagam, Pengyu Hong and Norbert Perrimon 9. Bayesian inference for model selection an application to aberrant signalling pathways in chronic myeloid leukaemia Lisa E. M. Hopcroft, Ben Calderhead, Paolo Gallipoli, Tessa L. Holyoake and Mark A. Girolami 10. Dynamic network models of protein complexes Yongjin Park and Joel S. Bader 11. Phenotype state spaces and strategies for exploring them Andreas Hadjiprocopis and Rune Linding 12. Automated behavioural fingerprinting of C. elegans mutants AndrÃƒÂ E. X. Brown and William R. Schafer Index. DispatchIn stock here - same-day dispatch from England. My SKU: 3275384RefundsNo-hassle refunds are always available if your book is not as expected.Terms and Conditions of SaleSorry - no collections. All sales are subject to extended Terms and Conditions of Sale as well as the Return Policy and Payment Instructions. Visit my eBay Store for details andmany more books. Template layout and design, "JNC Academic Books", "needbooks", Copyright © JNC INC. Designated trademarks, layouts and brands are the property of their respective owners. All Rights Reserved.

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