Description: Further DetailsTitle: Inducing Targeted Protein DegradationCondition: NewEAN: 9783527350131ISBN: 9783527350131Publisher: Blackwell Verlag GmbHFormat: HardbackRelease Date: 12/28/2022Description: Inducing Targeted Protein Degradation Enables drug developers in academia and industry to expand the range of accessible drug targets through induced protein degradation Since the breakthrough of the PROTAC technology in 2015, targeted protein degradation has revolutionized drug discovery, enabling pharma companies to develop completely novel therapeutics. Inducing Targeted Protein Degradation is a timely guide to navigating the complexities of the subject and understanding its practical application, with an eye on expanding the druggable space. In Inducing Targeted Protein Degradation, readers will find the most recent information on: Cellular mechanisms of targeted protein degradation and current approaches to utilize these mechanisms for drug discovery A comparison of different induced degradation approaches, including PROTAC, molecular glues, LYTACs and ATTECs as well as additional post translational modificationsDrug development aspects such as DMPK optimization and criteria for the selection of clinical candidatesA discussion of the potential of targeted degradation for expanding the druggable space Inducing Targeted Protein Degradation will serve as a practice-oriented reference on induced protein degradation for drug discovery professionals and for researchers employing chemical biology approaches.Language: EnglishCountry/Region of Manufacture: DEItem Height: 250mmItem Length: 179mmItem Width: 24mmItem Weight: 888gGenre: Science Nature & MathSubtitle: From Chemical Biology to Drug Discovery and Clinical ApplicationsContributor: Philipp Cromm (Edited by)Author: Philipp CrommRelease Year: 2022 Missing Information?Please contact us if any details are missing and where possible we will add the information to our listing.
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Book Title: Inducing Targeted Protein Degradation
Title: Inducing Targeted Protein Degradation
EAN: 9783527350131
ISBN: 9783527350131
Release Date: 12/28/2022
Release Year: 2022
Country/Region of Manufacture: DE
Genre: Science Nature & Math
Subtitle: From Chemical Biology to Drug Discovery and Clinical Applications
Contributor: Philipp Cromm (Edited by)
Number of Pages: 384 Pages
Publication Name: Inducing Targeted Protein Degradation : From Chemical Biology to Drug Discovery and Clinical Applications
Language: English
Publisher: Wiley & Sons, Incorporated, John
Subject: Clinical Medicine, Pharmacology
Publication Year: 2022
Item Height: 0.9 in
Type: Textbook
Item Weight: 31.1 Oz
Subject Area: Medical
Author: Philipp Cromm
Item Length: 9.6 in
Item Width: 6.7 in
Format: Hardcover
