Description: Non-invasive Device-Mediated Brain Drug Delivery across the Blood-Brain Barrier by Nicolas Tournier, Toshihiko Tashima It is well known that the blood-brain barrier (BBB), substantially composed of tight junctions between the capillary endothelial cells and efflux transporters such as MDR1 at the apical membrane of the capillary endothelial cells, prevents drugs from entering the brain. Accordingly, drug delivery into the brain across the BBB is a challenging task, particularly in central nervous system diseases such as Alzheimers disease and Parkinsons disease, as well as brain cancers such as glioma. It is true that drugs in systemic circulation go through intentional membrane disruption or intentional tight junction disruption into the brain across the BBB, but bystander harmful compounds can enter the brain together. Moreover, although craniotomy is often conducted for surgical removal or direct drug administration, this process burdens and torments patients. Thus, non-invasive, device-mediated brain drug delivery across the BBB should be developed to improve not only patient health, but also quality of life. At present, brain drug delivery systems that utilize biological transport machineries such as carrier-mediated transport, receptor-mediated transcytosis, lipid-raft-mediated transcytosis, or macropinocytosis at the BBB have been extensively investigated. This Special Issue aims to share recent progress and trends in this field. FORMAT Hardcover CONDITION Brand New Details ISBN3725806802 Author Toshihiko Tashima Pages 244 Publisher Mdpi AG Year 2024 ISBN-13 9783725806805 Format Hardcover Publication Date 2024-04-02 Imprint Mdpi AG Audience General We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:160052479;
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Format: Hardcover
ISBN-13: 9783725806805
Author: Nicolas Tournier, Toshihiko Tashima
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Book Title: Non-invasive Device-Mediated Brain Drug Delivery across the Blood
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