Nanoparticulate Vaccine Delivery Systems by Martin J. D'Souza (English) Hardcove

Description: Nanoparticulate Vaccine Delivery Systems by Martin J. D'Souza This book discusses studies conducted on a wide array of vaccines, including vaccines for infectious diseases such as tuberculosis, typhoid, influenza, pneumonia, meningitis, and hepatitis B. Studies on vaccine antigens suggest that this delivery system is highly suitable for antigens to be used for protective immunity. This method of vaccine delivery enables the delivery of a wide spectrum of vaccines for prophylactic and therapeutic use, including oral and transdermal vaccines for cancer such as human papillomavirus, melanoma, and ovarian, breast, and prostate cancer with encouraging results. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description Recent years have seen the development of novel technologies that use nanoparticles and microparticles to deliver vaccines by the oral and microneedle-based transdermal route of administration. These new technologies enable the formulation of vaccine particles containing vaccine antigens, without loss of their biological activity during the formulation process. Also, multiple antigens, targeting ligands, and adjuvants can all be encapsulated within the same particle. When administered orally, these particles are designed to withstand the acidic environment of the stomach and are targeted to Peyers patches and the gut-associated mucosal immune system. Since these vaccines are particulate in nature, they are readily taken up by phagocytic antigen-presenting cells, such as M cells, dendritic cells, and macrophages in Peyers patches of the intestines, resulting in a strong immune response and antibody production. Since no needles are required for oral vaccines, this method of vaccine delivery is inexpensive and suitable for mass vaccination in the developing world as well as the developed world. This book discusses studies conducted on a wide array of vaccines, including vaccines for infectious diseases such as tuberculosis, typhoid, influenza, pneumonia, meningitis, human papillomavirus, and hepatitis B. It also discusses recent studies on vaccines for cancers such as melanoma and ovarian, breast, and prostate cancer. Author Biography Martin J. DSouza is professor and director of Graduate Programs, College of Pharmacy, Mercer University, USA, co-director of the Center for Drug Delivery, and director of the Mercer Clinical Laboratory. He has published more than 90 articles in various journals and authored several book chapters and holds four patents. Prof. DSouzas research interests are in vaccines for infectious diseases and cancer. Table of Contents Introduction to Particulate Vaccine. Methods of Preparation of Nanoparticulate Vaccines. DOE. Routes of Administration. Case Studies. Meningitis Vaccine. TB Oral Vaccine. Cancer Vaccines. Influenza Vaccine. Melanoma Vaccine. Ovarian Cancer Oral Vaccine. Breast Cancer Oral Immunotherapy. Prostate Cancer Vaccine for Oral Delivery. Future Trends in Vaccine Delivery. Review "This book provides a detailed examination of the design, characterization, delivery, and efficacy of nanoparticulate vaccine delivery systems. It provides an excellent overview with in-depth case studies on the growing literature on novel vaccine delivery systems using nanoparticles."—Prof. Mark Prausnitz, Georgia Institute of Technology, USA"Readers will find introductory chapters on preparatory methods for micro/nanoparticles and formulation development and how these delivery systems interact with the immune system, followed by goal-orientated and detailed laboratory studies on nanoparticulate-based prokaryotic vaccines and cancer vaccines. Notably, the book provides several methods for non-parenteral antigen delivery, which is becoming increasingly important, particularly for the latest-generation vaccines against mucosal pathogens."—Prof. Myron Christodoulides, University of Southampton, UK"This book is a compelling force in the field of antigen delivery for infectious disease as well as cancer. It represents a thorough exploration of the nanoparticles ability to encapsulate diverse antigens, and immunostimulants, and deliver this payload to antigen-presenting cells, inducing an ensuing effective immune response."—Prof. Gary W. Bumgarner, Samford University, USA Review Quote "This book provides a detailed examination of the design, characterization, delivery, and efficacy of nanoparticulate vaccine delivery systems. It provides an excellent overview with in-depth case studies on the growing literature on novel vaccine delivery systems using nanoparticles." --Prof. Mark Prausnitz, Georgia Institute of Technology, USA "Readers will find introductory chapters on preparatory methods for micro/nanoparticles and formulation development and how these delivery systems interact with the immune system, followed by goal-orientated and detailed laboratory studies on nanoparticulate-based prokaryotic vaccines and cancer vaccines. Notably, the book provides several methods for non-parenteral antigen delivery, which is becoming increasingly important, particularly for the latest-generation vaccines against mucosal pathogens." --Prof. Myron Christodoulides, University of Southampton, UK "This book is a compelling force in the field of antigen delivery for infectious disease as well as cancer. It represents a thorough exploration of the nanoparticles ability to encapsulate diverse antigens, and immunostimulants, and deliver this payload to antigen-presenting cells, inducing an ensuing effective immune response." --Prof. Gary W. Bumgarner, Samford University, USA Details ISBN9814613304 Year 2015 ISBN-10 9814613304 ISBN-13 9789814613309 Format Hardcover Imprint Pan Stanford Publishing Pte Ltd Place of Publication Singapore Country of Publication Singapore DEWEY 614.47 Edited by Martin J. DSouza Publisher Pan Stanford Publishing Pte Ltd Short Title NANOPARTICULATE VACCINE DELIVE Language English Media Book Pages 244 Affiliation Mercer University, Atlanta, Georgia, USA Publication Date 2015-06-01 UK Release Date 2015-06-01 Illustrations 19 Illustrations, color; 61 Illustrations, black and white Author Martin J. DSouza Audience Tertiary & Higher Education We've got this At The Nile, if you're looking for it, we've got it. 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