Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer by Daniel L. Miller (

Description: Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer by Daniel L. Miller, M. Sharon Stack Moreover, individuals with HPV-positive OPSCC are generally younger and are frequently non-smokers, suggesting that HPV-associated OPSCC represents a distinct biologic entity.This volume summarizes the spectrum of current HPV-associated OPSCC research from the fundamental basic science to translational surgery and treatment approaches. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description Head and neck squamous cell carcinoma (HNSCC), the sixth most prevalent cancer worldwide, remains a very difficult disease to treat and cure despite intensive investigation into molecular etiologies and tumor progression pathways. Due to public health efforts encouraging smoking cessation, the overall incidence of HNSCC has decreased in recent years in many countries. In contrast, the incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased significantly, and this subtype of HNSCC is commonly associated with human papillomavirus (HPV) infection. Moreover, individuals with HPV-positive OPSCC are generally younger and are frequently non-smokers, suggesting that HPV-associated OPSCC represents a distinct biologic entity.This volume summarizes the spectrum of current HPV-associated OPSCC research from the fundamental basic science to translational surgery and treatment approaches. Chapters are contributed by authoritative leaders in the fields of research and clinical care. Initial chapters address epidemiology, behavioral correlates of HPV infection, and racial disparities in oropharyngeal cancer. This is followed by chapters detailing HPV virology with focus on viral transformation, viral replication, and host response to viral infection. The molecular biology of HPV-associated OPSCC is investigated in chapters detailing alterations in signaling networks and unique mutational profiles of human tumors. Clinical presentation, surgical perspectives, and treatment paradigms specific to HPV-associated OPSCC conclude the volume. This comprehensive volume provides an up-to-date overview of both scientific discovery and clinical management of this emerging public health problem. Back Cover Head and neck squamous cell carcinoma (HNSCC), the sixth most prevalent cancer worldwide, remains a very difficult disease to treat and cure despite intensive investigation into molecular etiologies and tumor progression pathways. Due to public health efforts encouraging smoking cessation, the overall incidence of HNSCC has decreased in recent years in many countries. In contrast, the incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased significantly, and this subtype of HNSCC is commonly associated with human papillomavirus (HPV) infection. Moreover, individuals with HPV-positive OPSCC are generally younger and are frequently non-smokers, suggesting that HPV-associated OPSCC represents a distinct biologic entity. This volume summarizes the spectrum of current HPV-associated OPSCC research from the fundamental basic science to translational surgery and treatment approaches. Chapters are contributed by authoritative leaders in the fields of research and clinical care. Initial chapters address epidemiology, behavioral correlates of HPV infection, and racial disparities in oropharyngeal cancer. This is followed by chapters detailing HPV virology with focus on viral transformation, viral replication, and host response to viral infection. The molecular biology of HPV-associated OPSCC is investigated in chapters detailing alterations in signaling networks and unique mutational profiles of human tumors. Clinical presentation, surgical perspectives, and treatment paradigms specific to HPV-associated OPSCC conclude the volume. This comprehensive volume provides an up-to-date overview of both scientific discovery and clinical management of this emerging public health problem. Table of Contents Epidemiology of HPV-Associated Oropharyngeal Squamous Cell Carcinoma.- Behavioral Correlates of HPV-Associated Oropharyngeal Squamous Cell Carcinomas.- Racial Disparities in Oropharyngeal Cancer.- HPV Virology: Cellular Targets of HPV Oncogenes and Transformation.- Papillomavirus Replication.- MicroRNA Profiles of HPV-Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC).- Targeting the PI3K-mTOR Signaling Circuitry in HPV-Associated Oral Malignancies: Novel Precision Molecular Therapies.- Mutational Profile of HPV-Positive HNSCC.- Clinical Presentation of HPV-driven Oropharyngeal Carcinoma.- Differences and Similarities between HPV-Associated OPSCC and Cervical Cancer.- Surgical Perspective in the Management of Oropharyngeal Cancer.- HPV and Radiation Sensitivity.- The Role of Immune Modulation in the Carcinogenesis and Treatment of HPV-associated Oropharyngeal Cancer. Feature Unique focus, as there is a dearth of material with a specific focus on HPV-associated oropharyngeal squamous cell carcinoma Topical, due to an increase of greater than 200% in cases of HPV-positive oropharyngeal cancer between 1984 and 2004 Approaches the subject from multiple perspectives, with an emphasis on virology Details ISBN3319210998 Year 2015 ISBN-10 3319210998 ISBN-13 9783319210995 Format Hardcover Short Title HUMAN PAPILLOMAVIRUS (HPV)-ASS Language English Media Book Pages 314 Edition 1st Imprint Springer International Publishing AG Place of Publication Cham Country of Publication Switzerland Edited by Daniel L. Miller DOI 10.1007/978-3-319-21100-8 Author M. Sharon Stack Publisher Springer International Publishing AG Edition Description 1st ed. 2015 Publication Date 2015-08-11 Alternative 9783319354781 DEWEY 616.99431 Audience Professional & Vocational Illustrations 22 Illustrations, color; 7 Illustrations, black and white; VIII, 314 p. 29 illus., 22 illus. in color. We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:129097853;

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