Effectiveness and Safety of Vitamin D in Relation to Bone Health: Evidence Repor

Description: Effectiveness and Safety of Vitamin D in Relation to Bone Health by Agency for Healthcare Resea And Quality, U.S. Department of Healt Human Services, Agency for Healthcare Resea Estimated delivery 3-12 business days Format Paperback Condition Brand New Description The University of Ottawa Evidence-based Practice Center (UO-EPC) reviewed and synthesized the published literature on five key questions. 1. Are specific circulating concentrations of 25 hydroxyvitamin D (25(OH)D) associated with bone health outcomes in: A. Children: rickets, bone mineral density (BMD), bone mineral content (BMC), fractures, or parathyroid hormone (PTH)? B. Women of reproductive age (including pregnant and lactating women): BMD, calcaneal ultrasound, fractures, PTH? C. Elderly men and postmenopausal women: BMD, fractures, falls? 2. Do food fortification, sun exposure, and/or vitamin D supplementation affect circulating concentrations of 25(OH)D? 3. What is the evidence regarding the effect of supplemental doses of vitamin D on bone mineral density and fracture or fall risk and does this vary with age groups, ethnicity, body mass index or geography? 4. Is there a level of sunlight exposure that is sufficient to maintain adequate vitamin D levels but does not increase the risk of non-melanoma or melanoma skin cancer? 5. Does intake of vitamin D above current reference intakes lead to toxicities (e.g., hypercalcemia, hypercalciuria, and calcification of soft tissue or major organs)? Osteoporosis-related fractures constitute an important socio-economic burden. The burden of fractures is expected to increase over the next two decades, with an expanding aging population. Effective treatment strategies that can be implemented on a population level are needed to decrease the burden of osteoporosis. Classical actions of vitamin D include the regulation of calcium homeostasis and the development and maintenance of the skeleton. Vitamin Ds major biologic function is to maintain serum calcium and phosphorus concentrations within the normal range by enhancing intestinal absorption of calcium and release of calcium and phosphorus from bone. Low vitamin D status has been associated with the development of rickets and osteomalacia, and has been considered to lead to bone loss, fractures and falls. Vitamin D also has non-calciotropic autocrine and paracrine functions, for example, in the regulation of cell differentiation and proliferation. The enzyme 1-alpha hydroxylase is present in many tissues in addition to the kidney, resulting in extra-renal production of 1,25-dihydroxyvitamin D. There is also emerging evidence for immunomodulatory and anti-infective properties of vitamin D. The increased suggestions of nutritional vitamin D insufficiency in the general population and the potential impact of vitamin D status on bone health and chronic health conditions have highlighted the need to reassess current vitamin D reference intakes. Over the last few years, a number of large randomized trials have evaluated the effect of vitamin D supplementation on fractures, falls and harms. A systematic review was conducted to synthesize the most recent evidence and address the above questions. Details ISBN 149950036X ISBN-13 9781499500363 Title Effectiveness and Safety of Vitamin D in Relation to Bone Health Author Agency for Healthcare Resea And Quality, U.S. Department of Healt Human Services, Agency for Healthcare Resea Format Paperback Year 2014 Pages 358 Publisher Createspace Independent Publishing Platform GE_Item_ID:93263966; About Us Grand Eagle Retail is the ideal place for all your shopping needs! With fast shipping, low prices, friendly service and over 1,000,000 in stock items - you're bound to find what you want, at a price you'll love! Shipping & Delivery Times Shipping is FREE to any address in USA. Please view eBay estimated delivery times at the top of the listing. Deliveries are made by either USPS or Courier. We are unable to deliver faster than stated. International deliveries will take 1-6 weeks. NOTE: We are unable to offer combined shipping for multiple items purchased. This is because our items are shipped from different locations. Returns If you wish to return an item, please consult our Returns Policy as below: Please contact Customer Services and request "Return Authorisation" before you send your item back to us. Unauthorised returns will not be accepted. Returns must be postmarked within 4 business days of authorisation and must be in resellable condition. Returns are shipped at the customer's risk. We cannot take responsibility for items which are lost or damaged in transit. For purchases where a shipping charge was paid, there will be no refund of the original shipping charge. Additional Questions If you have any questions please feel free to Contact Us. Categories Baby Books Electronics Fashion Games Health & Beauty Home, Garden & Pets Movies Music Sports & Outdoors Toys

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