Description: Design and development of nano based ophthalmic drug delivery system by Joshi Hardik Estimated delivery 3-12 business days Format Paperback Condition Brand New Description Eye as a target for the drug delivery systems presents some unique challenges owing to its physiologic and anatomical characteristics. Systemic administration of drugs for ocular effect necessitates large doses to achieve sufficient concentration in the ocular tissues, leading to unwanted side effects. Though it is more convenient to administer the drugs directly into the exterior cu de sac of the eye, this approach suffers from poor residence time and consequently limited corneal permeation. Prednisolone acetate (PA) is a topical anti-inflammatory agent used in the treatment of steroid-responsive inflammation of palpebral and bulbar conjunctiva, cornea and anterior segments of the globe. PA is available as microfine suspension owing to its aqueous insolubility. Suspensions are known to be inherently physically unstable, and the dose-to-dose uniformity is patient-dependant. Therefore, the aim of the present study was to formulate nanoemulsion and liposomes of PA for ophthalmic drug delivery which would overcome the problems associated with eye drops in general and suspensions in particular. Nanoemulsion was prepared using De novo emulsion approach. Solubility studies using saturation shake-flask method were carried out to identify suitable oil and surfactant for the preparation of nanoemulsion. Process variables for microfluidization were optimized using a three-level, three-factor Box-Behnken design. Nanoemulsion was evaluated for drug content, globule size, pH, osmolality, zeta potential, viscosity, surface morphology, and in-vitro drug release. The viscosity of the optimized nanoemulsion was adjusted between 15 cps and 25 cps using a suitable polymer. The critical quality attributes like viscosity and osmolality of different polymers like chitosan, carbomer 974P and polycarbophil were evaluated for this purpose. The developed viscous nanoemulsion was characterized for drug content, globule size, pH, osmolality, zeta potential, viscosity, rheology, sedimentation study, surface morphology and in-vitro drug release. Details ISBN 1805450697 ISBN-13 9781805450696 Title Design and development of nano based ophthalmic drug delivery system Author Joshi Hardik Format Paperback Year 2022 Pages 196 Publisher Independent Aurthor GE_Item_ID:139619480; About Us Grand Eagle Retail is the ideal place for all your shopping needs! With fast shipping, low prices, friendly service and over 1,000,000 in stock items - you're bound to find what you want, at a price you'll love! Shipping & Delivery Times Shipping is FREE to any address in USA. Please view eBay estimated delivery times at the top of the listing. Deliveries are made by either USPS or Courier. We are unable to deliver faster than stated. International deliveries will take 1-6 weeks. NOTE: We are unable to offer combined shipping for multiple items purchased. This is because our items are shipped from different locations. Returns If you wish to return an item, please consult our Returns Policy as below: Please contact Customer Services and request "Return Authorisation" before you send your item back to us. Unauthorised returns will not be accepted. Returns must be postmarked within 4 business days of authorisation and must be in resellable condition. Returns are shipped at the customer's risk. We cannot take responsibility for items which are lost or damaged in transit. For purchases where a shipping charge was paid, there will be no refund of the original shipping charge. Additional Questions If you have any questions please feel free to Contact Us. Categories Baby Books Electronics Fashion Games Health & Beauty Home, Garden & Pets Movies Music Sports & Outdoors Toys
Price: 32.11 USD
Location: Fairfield, Ohio
End Time: 2025-01-31T07:27:29.000Z
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Format: Paperback
ISBN-13: 9781805450696
Author: Joshi Hardik
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Book Title: Design and development of nano based ophthalmic drug delivery sys
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